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Further to the individual study results, pooled meta-analysis of over 60,000 patients enrolled in the eight major phase 3 GLP-1 RA trials, of whom 72.4% had established CVD, concluded that GLP-1 RA therapy achieves a relative reduction in MACEs of 14% (HR 0.86, 95% CI [0.80–0.93], p 80% had preexisting CVD [50,59]
